Absorbable hydrodissection fluids

Project Overview

Hydrodissection is used to protect adjacent organs during percutaneous thermal ablation. Current techniques involve the injection of 5% dextrose with water (D5W) or saline. Although effective in protecting surrounding tissue, these solutions tend to migrate into the body cavity which results in the need for large amounts of solution to remain effective (approximately one liter). The goal of this project is to develop a solution/gel that encompasses favorable aspects of the current solutions: easy to introduce, ultrasound transparent, visible on CT/MRI, biocompatible, absorbable, thermally and electrically insulating, and relatively low cost; but also puts a stop to solution migration into the body cavity.