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Implantable light source for optogenic alteration of immune response

Project Overview

Optogenic activation or blocking of neurons is well established and now we use that approach to alter immune cell functions in mice to understand inflammatory responses in brain (Dr. Fabry)and lung diseases (Dr. Sandor) We have the mice that express light sensitive ionchannels in dendritic cells (an initiator of immunity) and in vitro we have showed they alter Ca uptake of these cells.

In vivo light delivery is key to that project. Last year one of your team created implantable bluetooth lightsource that is very relevant for us. Nerve activation may need a small site to be lighted. We need a solution for 470nm and possible 405 nm light that can deliver light to a larger are (about 1cm diagonal) and can be switched on -off for hours in the animal. That approach will study immunity in an animal model of multiple sclerosis (Dr. Fabry) and tuberculosis Dr. Sandor.

Team Picture

Team members from left to right: Ruochen(Team leader), Hanna(Communicator), Lisa(BWIG), Jacky(BPAG,BSAC)
Team members from left to right: Ruochen(Team leader), Hanna(Communicator), Lisa(BWIG), Jacky(BPAG,BSAC)

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Contact Information

Team Members

  • Ruochen Wang - Team Leader
  • Hanna Rainiero - Communicator
  • Jacky Tian - BSAC & BPAG
  • Lisa Xiong - BWIG

Advisor and Client

  • Prof. Justin Williams - Advisor
  • Prof. Matyas Sandor - Client
  • Martin Hsu - Alternate Contact

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