Project Overview

A method of microencapsulating Leydig cells for the long-term time release of male reproductive hormones in vivo is desired. Challenges such as biocompatibility, patient immune response, and perfusion of encapsulated cells must be addressed. The current design uses a polyethylene glycol diacrylate (PEGDA) polymer mixed with a cell suspension. Microcapsule production may be achieved with a microfluidics approach, followed by UV light exposure to cause polymerization, or cross-linking, of the polymer-cell mixture into a stable hydrogel.

Files

• BME 400 (Fall 2005) Final Report (February 1, 2006)
• BME 400 (Fall 2005) Final Poster (February 1, 2006)
• Product Design Specifications (2/1/06) (February 1, 2006)
• BME 402 Midsemester Presentation (March 1, 2006)

Contact Information

Team Members

• Bryan Baxter - Team Leader
• Joseph Zechlinski - Communicator & BWIG
• Timothy Eng - BSAC

Advisor and Client

• Dr. Kristyn Masters - Advisor
• Dr. Craig Atwood - Client

Related Projects

• Spring 2007: Microencapsulation of tissues and cells for treatment of hormone-related diseases.
• Fall 2006: Microencapsulation of tissues and cells for treatment of hormone-related diseases
• Spring 2006: Microencapsulation of Leydig Cells
• Fall 2005: Microencapsulation of tissues and cells for treatment of hormone-related diseases