Skip to main content

Synthetic bowel tissue development

Project Overview

Design a synthetic bowel tissue incorporating the two distinct layers of the small bowel (the mucosa and the muscularis) that replicates animal tissue both physically and aesthetically. This model is designed as a simulation model on which residents can be assessed in their knowledge of procedures such as bowel repair, resection, and anastomosis. This small bowel design will employ a user-friendly fabrication protocol and packaged kit to aid in mass production and accessibility.

Team Picture

Team members from left to right: Ryan Serbin, Molly Scott, Andrea Doll
Team members from left to right: Ryan Serbin, Molly Scott, Andrea Doll

Images

Synthetic Bowel Fabrication: A schematic showing the steps of how the second generation prototype was fabricated. Labels A-H are noted in each photo’s upper right corner. A) Fabricating cellulose sheath B) Placing preformed sheath on inner PVC mold C) Wrapping inner tube from (B) in cotton matrix D) Coloring DragonSkin/Slacker and EcoFlex Gel for small bowel and mesentery E) Spreading Smooth-On from (D) onto wrapped pipe from (C) F) Securing pipe/cotton matrix/silicone complex in outer mold G) Pouring yellow EcoFlex Gel onto cotton matrix to form mesentery H) Adding vasculature to the mesentery.
Synthetic Bowel Fabrication: A schematic showing the steps of how the second generation prototype was fabricated. Labels A-H are noted in each photo’s upper right corner. A) Fabricating cellulose sheath B) Placing preformed sheath on inner PVC mold C) Wrapping inner tube from (B) in cotton matrix D) Coloring DragonSkin/Slacker and EcoFlex Gel for small bowel and mesentery E) Spreading Smooth-On from (D) onto wrapped pipe from (C) F) Securing pipe/cotton matrix/silicone complex in outer mold G) Pouring yellow EcoFlex Gel onto cotton matrix to form mesentery H) Adding vasculature to the mesentery.
Dr. Nathwani running a stitch through the synthetic small bowel prototype. B) the synthetic small bowel post-resection and anastomosis simulation.
Dr. Nathwani running a stitch through the synthetic small bowel prototype. B) the synthetic small bowel post-resection and anastomosis simulation.

Files

Contact Information

Team Members

  • Molly Scott - Team Leader
  • Andrea Doll - Communicator & BWIG & BPAG
  • Ryan Serbin - BSAC

Advisor and Client

  • Prof. Tracy Jane Puccinelli - Advisor
  • Mr. Calvin Kwan - Client
  • Shannon Dimarco - Alternate Contact

Related Projects

Back to Top