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Proteovista: Multiplex chamber for high throughput DNA-based therapeutic screening

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Project Overview

At Proteovista, scientists developed a SNAP (Specificity and Affinity for Proteins) Screen Microarray and hybridization chamber to test the affinity and specificity of proteins and cell lysates on target strands of DNA. The array is currently in an 8-plex format, whereby each plex contains its own set of DNA features that can be tested against a combination of small molecules. The clients would like to develop the SNAP-Screen platform into a higher-throughput system by expanding to a 384 well plate format with 52 plexes. The 52-plex chamber should adhere to the microarray slide during a variety of protocols, while also remaining watertight and easily removable. Each of the 52 plexes should be the same size. Additionally, the chamber should be compatible with a robotic liquid handling machine that can load reagents into the plexes as part of a high-throughput system. This expanded multiplex chamber design will allow the client to test small molecules individually, increasing the significance of their results.

Team Picture

Team members from left to right: Bella Reichardt, Kelsey Murphy, Ryan Opansky, Allie Walker
Team members from left to right: Bella Reichardt, Kelsey Murphy, Ryan Opansky, Allie Walker

Contact Information

Team Members

  • Kelsey Murphy - Team Leader
  • Isabella Reichardt - Communicator
  • Alyssa Walker - BSAC & BPAG
  • Ryan Opansky - BWIG

Advisor and Client

  • Prof. Pamela Kreeger - Advisor
  • Dr. Mary Ozers - Client
  • Dr. Christopher Warren - Alternate Contact
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