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Intracranial EEG phantom for brain stimulation studies

The goal of this project is to develop a pediatric brain phantom model that can be used to simulate the main effects of TMS on iEEG electrodes: currents, temperatures, and changes in position.

Project Overview

Intracranial electroencephalography (iEEG) is routinely used in surgical planning for individuals with uncontrolled seizures, such as those with epilepsy. Utilizing electrode systems either connected across the surface of or implanted into the brain, this method provides high spatiotemporal resolution. Transcranial magnetic stimulation (TMS) assesses brain circuit excitability through electromagnetic induction, inducing currents to produce action potentials and painlessly activate brain networks. While this neuromodulation technique may provide complementary information for mapping out critical brain regions that should be avoided during surgery, there are several safety concerns around the use of TMS in patients with iEEG: that of secondary electrical currents, heating of the implanted electrodes, and electrode array displacement, all of which would have severe consequences for the affected individuals. Additionally, the impact of these techniques has not been previously studied on children with epilepsy, but instead on adult patients; dissimilar physiology and comparative higher resting motor thresholds might require higher levels of stimulation, both of which indicate the need for adjusted treatment.

Team Picture

Team from left to right: Helene Schroeder, Lilly Mackenzie, Avery Schuda, Orla Ryan, Corissa Hutmaker
Team from left to right: Helene Schroeder, Lilly Mackenzie, Avery Schuda, Orla Ryan, Corissa Hutmaker

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