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Cancer Cell Scaffold for C13 MRI Hyperpolarization Studies

Project Overview

Assessing the progression and response to treatment of cancer may be possible by characterizing the metabolic state of cancer cells. Currently, our client uses MRI hyperpolarized carbon-13 labeled pyruvate to evaluate the metabolism of cancer. The objective of our project is to develop a cell scaffold for maintaining the cancer cells within a MR-compatible bioreactor. Cells must adhere and proliferate on this scaffold to sufficiently high densities and sustain viability for visualization of the pyruvate.

Team Picture

Team members from left to right: Sara, Vivien Chen, Sarah Czaplewski, Vanessa Grosskopf, and Josh Kolz.
Team members from left to right: Sara, Vivien Chen, Sarah Czaplewski, Vanessa Grosskopf, and Josh Kolz.

Images

Image (20x magnification) of a collagen coated bead seeded with T99 glioblastoma cells demonstrating excellent cell attachment.
Image (20x magnification) of a collagen coated bead seeded with T99 glioblastoma cells demonstrating excellent cell attachment.
Image (20x magnification) of plain polystrene beads seeded with T99 glioblastoma cells showing limited cell attachment.
Image (20x magnification) of plain polystrene beads seeded with T99 glioblastoma cells showing limited cell attachment.
Image (10x magnification) of collagen coated beads seeded with T47D breast cancer cells demonstrating good cell attachment.
Image (10x magnification) of collagen coated beads seeded with T47D breast cancer cells demonstrating good cell attachment.
Image (10x magnification)of plain polystyrene beads seeded with T47D breast cancer cells showing limitated cell attachment.
Image (10x magnification)of plain polystyrene beads seeded with T47D breast cancer cells showing limitated cell attachment.

Files

Contact Information

Team Members

  • Joshua Kolz - Team Leader
  • Vanessa Grosskopf - Communicator
  • Feng Chen - Co-BSAC
  • Prof. Sarah Sandock - Co-BSAC
  • Sarah Czaplewski - BWIG

Advisor and Client

  • Prof. Brenda Ogle - Advisor
  • Sean Fain - Client
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