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Tissue biopsy dissociation

Project Overview

Biological research often requires the study of individual cells to gain a better understanding of processes within the human body. The client’s research on asthma has focused on the use of tissue biopsy dissociation to obtain individual cells. The research is specifically interested in studying cells before and after an induced asthmatic response. The current device being used for this process, the gentleMACS™ Dissociation Device, does not allow for use of a small tissue sample size. A small tissue sample size, 1-2 mm, is desired to reduce the recovery time and pain of the patient. The team is tasked to create a dissociation device that will successfully dissociate smaller tissue samples and yield viable cells to study. The most important criterion is the ability of the design to perform appropriately and yield at least 50% viable cells. The team is currently working on a microfluidic channel which utilizes shear forces to separate cells from the tissue.

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Team pictured, from left to right: Dr. Saha (Team Advisor), Tommy, Chrissy, Raven, Nate, Lauren
Team pictured, from left to right: Dr. Saha (Team Advisor), Tommy, Chrissy, Raven, Nate, Lauren

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Contact Information

Team Members

  • Lauren Ross - Team Leader
  • Chrissy Kujawa - Communicator
  • Raven Brenneke - BSAC
  • Nathan Richman - BWIG
  • Thomas Guerin - BPAG

Advisor and Client

  • Dr. Kris Saha - Advisor
  • Dr. Sameer Mathur - Client

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