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3D Scaffold for Schwann Cell Culture and Myelination

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Project Overview

This projects aims to provide the unique culture ability to study Schwann cell myelination in vitro. Current methods of studying myelination of the peripheral nervous system in vitro are inadequate, as they contain too many variables or do not provide the 3 dimensional environment required for proper myelination by Schwann Cells. This project intends to mimic the morphology and chemistry of peripheral nervous system (PNS) axons with synthetic materials and appropriate proteins. This will ultimately provide Schwann cells with a means of myelinating these artificial axons to best simulate the in vivo environment while simultaneously isolating the cells. This scaffold will therefore provide optimal conditions for drug screening against disorders such as CMT-1A.

Team Picture

Team members from left to right: Nick Shiley, Courtney Kreuger, Brad Lindevig (since graduated), David Schreier, Jacob Meyer
Team members from left to right: Nick Shiley, Courtney Kreuger, Brad Lindevig (since graduated), David Schreier, Jacob Meyer

Contact Information

Team Members

  • Courtney Krueger - Team Leader
  • David Schreier - Communicator
  • Nicholas Shiley - BSAC
  • Jacob Meyer - BWIG

Advisor and Client

  • Prof. John Puccinelli - Advisor
  • Dr. John Svaren - Client

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