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Alternative Epinephrine Delivery Method During Anaphylaxis for Pediatric Patients

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Oral delivery method for epinephrine that will effectively counteract the symptoms of anaphylaxis in pediatric patients.

Design Award

  • BME and UWSMPH-TECH Collaborative Innovation Award Winner

Project Overview

Anaphylaxis is caused by a hypersensitivity reaction to a benign antigen. These reactions can be very severe and need to be treated immediately. Although the occurrence of anaphylaxis is increasing for all ages, children of ages 5-9 are most commonly affected. Therefore, this project will focus on treatment of pediatric patients.

Current treatment methods for anaphylaxis include intramuscular epinephrine injection into the upper thigh of a patient. This which increases blood pressure and flow by increasing peripheral vascular resistance. This method involves the use of an EpiPen, a self-injectable applicator. Although the EpiPen is well known and commonly used, there are many factors that contribute to the need for an alternative administration method. Some of which include: high cost, high usage of expired EpiPens, failure to educate parents and subjects on how to properly use the device, fear of needles, and a very limited variety of doses.

The scope of this project includes developing a dissolving tablet to administer to children while they are experiencing anaphylactic shock. Benefits of this treatment method include easy administration, minimal required training, a longer shelf-life, direct administration into the bloodstream, and the opportunity to create a larger variety of doses to increase the efficiency of the drug.

Team Picture

Team Members (Left to Right): (Back) - Gwendolyn Johnson, Marisa Vattendahl Vidal (Front) - Alexus Edwards, Katarina Martinet, Sophia Nehs
Team Members (Left to Right): (Back) - Gwendolyn Johnson, Marisa Vattendahl Vidal (Front) - Alexus Edwards, Katarina Martinet, Sophia Nehs

Contact Information

Team Members

  • Sophia Nehs, BME 402 - Team Leader
  • Katarina Martinet, BME 402 - Communicator
  • Alexus Edwards, BME 402 - BSAC
  • Gwendolyn Johnson, BME 402 - BWIG
  • Marisa Vattendahl Vidal, BME 402 - BPAG
  • Alyssa Fleischman, Medical Student
  • Grigor Simitian, Medical Student

Advisor and Client

  • Dr. John Puccinelli - Advisor
  • Dr. Lenard Markman - Client

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