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Microfluidic sensing chip: Combined light-stimulating and measurement system

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The goal of this project is to create a device that can detect the presence of endocrine disrupting compounds in yeast cells by detecting the presence of GFP.

Project Overview

Endocrine disrupting compounds (EDC’s) are exogenous agents that work with the endocrine system, sometimes mimicking endocrine compounds, to interfere with all of the functions of the endocrine system (i.e. synthesis, hormone signaling, secretion, etc.). The yeast cells provided by the client will detect these compounds and express DNA that leads to the transcription/translation of green fluorescent proteins (GFP). Another microfluidic chip group is developing a chip which will house these cells in multiple wells with an interface that will work with this group’s half of the project.
The overall goal of the project is to help bridge the gap between biological sensors and electronic circuits. The objective is to design a device that can fluoresce the GFP in the EDC sensing yeast cells on a microfluidic chip through the use of a specific wavelength of light. Once the yeast cells are activated, the device should also sense the wavelength of fluorescence radiating from the yeast cells once they sense EDCs.

Team Picture

Pictured left to right: Adam Ebenhoeh, William Dunn V, Jack Ruhland, and Navjot Rehal
Pictured left to right: Adam Ebenhoeh, William Dunn V, Jack Ruhland, and Navjot Rehal

Contact Information

Team Members

  • William Dunn V - Team Leader & BPAG
  • Jack Ruhland - Communicator
  • Navjot Rehal - BSAC
  • Adam Ebenhoeh - BWIG

Advisor and Client

  • Dr. Alireza Ashtiani - Advisor
  • Dr. Aviad Hai - Advisor
  • Prof. Megan McClean - Client
  • Prof. Bhuvana Krishnaswamy - Alternate Contact

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