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Point of care biosensor microfluidic cartridge

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A microfluidic cartridge that filters a sample of whole blood and delivers it to a biosensor as a Point of Care service.

Project Overview

Point-of-Care (POC) diagnostic biosensors play a critical role in public health. Many optical biochemical sensors are based on assays that require blood serum or plasma samples. However, extracting serum or plasma from whole blood requires specific equipment that is not compatible with the point-of-care settings. Therefore, there is a critical need for rapid, reliable and low-cost microfluidic lateral flow cartridges to disseminate new biosensors for POC applications. The expectation from this project is to design a microfluidic device that can be assembled into nanoplasmonic biosensors (chip area=1 cm2, thickness=0.5 um) that are developed in the Yesilkoy Lab. The final device should take a small quantity (100 μL) of whole blood from a finger prick, filter blood cells from whole blood within minutes (less than 30 mins), and transfer the filtered blood sample (> 25 μL) into a measurement chamber where the quantitative bioassay will take place. The total cost of the cartridge should not exceed 5$ in the final manufacturing and 50$ in the research & development phase.

Team Picture

Left to Right: Ryan Granowski, Harshal Kanade, Michael DelSignore, Riley Smith, Simon Zulewski
Left to Right: Ryan Granowski, Harshal Kanade, Michael DelSignore, Riley Smith, Simon Zulewski

Contact Information

Team Members

  • Harshal Kanade - Team Leader
  • Simon Zulewski - Communicator
  • Ryan Granowski - BSAC
  • Michael Del Signore - BWIG
  • Riley Smith - BPAG

Advisor and Client

  • Stephen Foley - Advisor
  • Prof. Megan McClean - Advisor
  • Prof. Filiz Yesilkoy - Client

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