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JangoBio: Designing single and multi spinner flasks for organoid culture

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Cell culturing vessel that suspends organoids in culture using acoustic waves in collaboration with JangoBio, a biotechnology company investigating regenerative stem cell therapies in Madison.

Project Overview

Culturing organoids requires the use of well-designed, spinning culture vessels to facilitate their formation from isolated stem cells. Current designs for spinner flasks and spinning bioreactors are expensive and not well suited for smaller-scale research purposes. Therefore, there is a need for a small volume, multi-well, spinning bioreactor that is reusable, inexpensive, and has the ability to modulate the rotation of each well individually for niche research purposes. The current prototype uses a hydrogel to transfer the acoustic waves. However, gel used now lasts up to 48 hours due to the drying nature of incubators. Additionally, frequent gel switching could cause interference with the culturing of the organoids. A gel that could appropriately conduct acoustic waves and lasts up to two weeks in the incubator could address this problem.

Team Picture

Top Row, Left to Right: Olivia Jaekle, Bella Zingler-Holset, Hailey Kanter; Bottom Row, Left to Right: Rebecca Shomaker and Kevin Zhang
Top Row, Left to Right: Olivia Jaekle, Bella Zingler-Holset, Hailey Kanter; Bottom Row, Left to Right: Rebecca Shomaker and Kevin Zhang

Contact Information

Team Members

  • Hailey Kanter - Team Leader
  • Kevin Zhang - Communicator
  • Rebecca Shomaker - BSAC
  • Olivia Jaekle - BWIG
  • Bella Zingler-Hoslet - BPAG
  • Christopher Wiegand

Advisor and Client

  • Prof. Wan-Ju Li - Advisor
  • Dr. Craig Atwood - Client
  • Sivan Vadakkadath Meethal - Alternate Contact

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